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Gold Derivatives Development as Prospective Anticancer Drugs for Breast Cancer Treatment

Articolo
Data di Pubblicazione:
2021
Citazione:
(2021). Gold Derivatives Development as Prospective Anticancer Drugs for Breast Cancer Treatment [journal article - articolo]. In APPLIED SCIENCES. Retrieved from http://hdl.handle.net/10446/177156
Abstract:
Commonly used anticancer drugs are cisplatin and other platinum‐based drugs. However, the use of these drugs in chemotherapy causes numerous side effects and the onset of frequent drug resistance phenomena. This review summarizes the most recent results on the gold derivatives used for their significant inhibitory effects on the in vitro proliferation of breast cancer cell models and for the consequences deriving from morphological changes in the same cells. In particular, the study discusses the antitumor activity of gold nanoparticles, gold (I) and (III) compounds, gold complexes and carbene‐based gold complexes, compared with cisplatin. The results of screening studies of cytotoxicity and antitumor activity for the gold derivatives show that the death of cancer cells can occur intrinsically by apoptosis. Recent research has shown that gold (III) compounds with square planar geometries, such as that of cisplatin, can intercalate the DNA and provide novel anticancer agents. The gold derivatives described can make an important contribution to expanding the knowledge of medicinal bioorganometallic chemistry and broadening the range of anticancer agents available, offering improved characteristics, such as increased activity and/or selectivity, and paving the way for further discoveries and applications.
Tipologia CRIS:
1.1.01 Articoli/Saggi in rivista - Journal Articles/Essays
Elenco autori:
Ielo, Ileana; Iacopetta, Domenico; Saturnino, Carmela; Longo, Pasquale; Galletta, Maurilio; Drommi, Dario; Rosace, Giuseppe; Sinicropi, Maria Stefania; Plutino, Maria Rosaria
Autori di Ateneo:
ROSACE Giuseppe
Link alla scheda completa:
https://aisberg.unibg.it/handle/10446/177156
Link al Full Text:
https://aisberg.unibg.it/retrieve/handle/10446/177156/403184/2021%20Gold%20Derivatives%20Development%20as%20Prospective%20Anticancer%20Drugs%20for%20Breast%20Cancer%20Treatment.pdf
Pubblicato in:
APPLIED SCIENCES
Journal
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Settore CHIM/07 - Fondamenti Chimici delle Tecnologie
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